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Acta Gastroenterologica Belgica is supported by grants
from its major sponsors
Acta Gastro-Enterologica Belgica is published in
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Reviews
"A review of the literature on three extraintestinal complications of ulcerative colitis : an ulcerative colitis flare complicated by Budd-Chiari syndrome, cerebral venous thrombosis and idiopathic thrombocytopenia"Price: €10,00 |
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| Extraintestinal manifestations are well described and recognized
in association with ulcerative colitis. Immunologically mediated
and thrombotic events are among the more rare manifestations
associated
with flares. These manifestations include Budd-Chiari
syndrome, idiopathic thrombocytopenia, and cerebral venous
thrombosis. A 22 year-old male with a three-year history of
ulcerative
colitis presented with worsening hematochezia, fatigue,
headache and upper respiratory symptoms. Laboratory evaluation
demonstrated a platelet count of 24 × 109/L (normal baseline platelet
count noted 3 months prior) and hemoglobin of 8.6 × 109/L.
Imaging
demonstrated hepatic venous thrombosis consistent with
Budd-Chiari syndrome and cerebral venous thrombosis. Based on
peripheral smear analysis and eventual marked response to
steroids,
a diagnosis of idiopathic thrombocytopenia was made. He
was started on prednisone 40mg daily with brisk improvement in
both his ulcerative colitis flare and his platelet count increasing
above 100 × 109/L. He was therapeutically anticoagulated for the
cerebral venous thrombosis. He continued to do well and was
discharged
on therapeutic enoxaparin and a 40 mg prednisone
taper
without recurrent flare or idiopathic thrombocytopenia two
weeks post-hospitalization. To our knowledge, this is the first
report
of all three known but rare complications diagnosed concurrently
in the same patient. This review examines three extraintestinal
complications of ulcerative colitis, including the presentation,
diagnosis, and treatment. (Acta gastroenterol.
belg., 2013, 76, 311-
316). [Product Details...] |
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Alveolar Echinococcosis in a Belgian Urban DwellerPrice: €10,00 |
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| Human alveolar echinococcosis is a rare parasitic disease caused
by larvae of the tapeworm E. multilocularis that colonizes the intestines
of foxes. The disease predominantly affects the liver and
mimics
slow growing liver cancer. With a mere 13 reports coming
mostly from southern rural regions Belgium has so far been spared
from the disease. However alveolar echinococcosis appears to be
slowly spreading to non-endemic European countries like Belgium
and to urban centres. We report the first autochthonous case
involving
a patient having lived exclusively in downtown Brussels.
Heightened awareness by the medical community is necessary to
detect this lethal disease at an early curable stage. In patients with
an undetermined focal liver lesion – especially if calcified – and no
firm evidence of malignancy, serological screening should be performed
to exclude alveolar echinococcosis. (Acta gastroenterol.
belg.,
2013, 76, 317-321). [Product Details...] |
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The use of fecal calprotectin and lactoferrin in patients with IBD. Review.Price: €10,00 |
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| Endoscopy has been the gold standard for diagnosing and following
patients with inflammatory bowel disease. However, ileocolonoscopy
is still an expensive and invasive method. Secondly we do
know that clinical scores for ulcerative colitis and Crohn’s disease
are subjective which creates several problems. And thirdly, when
using the known serological markers such as C-reactive protein,
white blood cell count en albumin, one should take into account
that these markers are not perfect or superior to the current diagnostic
techniques given their low sensitivity and specificity.
Fecal markers may prove to have a greater specificity. Calprotectin
can differentiate between active and inactive inflammatory
bowel disease and between inflammatory bowel disease and irritable
bowel syndrome. It correlates with the severity of symptoms
and it may predict relapse especially in ulcerative colitis. Finally it
can be used as a surrogate marker for the endoscopic response during
treatment given a normal value of calprotectin is a reliable
marker for mucosal healing. Lactoferrin also seems to be a sensitive
and specific marker for the detection of chronic inflammation
and for predicting relapse. The relationship with the endoscopic
activity is significant and lactoferrin values are significantly higher
in active endoscopic disease as compared to inactive disease.
Finally,
given the significant correlation with endoscopic activity,
lactoferrin can function as an adequate marker for the monitoring
of therapy. (Acta gastroenterol.
belg., 2013, 76, 322-328). [Product Details...] |
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Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica