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Original Article
Evaluation of the GERD Impact Scale, an international, validated patient questionnaire, in daily practice. Results of the ALEGRIA studyPrice: €10,00 |
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Background and study aims : Gastroesophageal reflux disease
(GERD) is a common chronic disease that is primarily diagnosed
based on symptom severity and frequency. This study gathered
epidemiological data in a population of GERD patients and
evaluated the added-value of the GERD Impact Scale (GIS), a
novel, validated patient questionnaire, as a tool for initial and longterm
patient management.
Patients and methods : This observational study recruited
patients (296 study centers) with symptomatic GERD and a
history of erosive, or reflux, esophagitis. Symptoms were assessed
by GIS and physician-subject interview and recorded at baseline
(visit 1), at 4–6 weeks (visit 2) and 8–14 weeks (visit 3) ; also
recorded at each visit was the physician’s assessment of GERD
severity and treatment changes. Analyses were performed on an
intent-to-treat basis.
Results : Subjects (n=1919 ; mean age, 55 years) were 54%
female. Lifestyle characteristics included stress (~70% of subjects),
mean daily consumption of five cups of caffeine-containing beverages
(~70%), alcohol consumption of approximately nine units per
week (~50%) and smoking/ex-smoker (41%). Proton pump
inhibitors were prescribed in 99% of cases : mainly esomeprazole
(82%), with a median dose of 40 mg. Prescribed therapy was
changed (mainly dosage levels) between visits in ~60% of subjects.
The severity of GERD symptoms and GIS scores decreased substantially
throughout the study. Mean GIS scores correlated positively
with increasing GERD severity and clinical judgment at all
visits. Physicians reported that the GIS helped them define the
appropriate treatment for the patient and to evaluate the patient’s
response to treatment in 81% of cases.
Conclusions : This study demonstrates the added-value and
usefulness of the patient self-assessment GIS as a management tool
for GERD. (Acta gastro enterol. belg., 2009, 72, 3-8). [Product Details...] |
Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica