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Case series
Eosinophilic esophagitis that develops during therapy with proton pump inhibitors : case series and possible mechanismsPrice: €10,00 |
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Therapy with proton-pump inhibitors (PPIs) results in remission
in at least one third of patients with esophageal eosinophilia,
presumably because of both their acid-related and anti-inflammatory
mechanisms of action. However, eosinophilic esophagitis
(EoE) may also develop during therapy with PPIs. We present a
case series of four children who were initially diagnosed with infectious
esophagitis, gastroesophageal reflux disease or gastric ulcer,
who had no eosinophilic infiltration of the esophagus, but subsequently
developed symptoms, endoscopic features and histological
picture of typical EoE. We discuss mechanisms of action of PPIs of
likely relevance to an increased risk of development of EoE in some
patients , such as their influence on mucosal barrier function, interference
with pH-related protein digestion by pepsin, and antigen
processing by immune cells. (Acta gastroenterol.
belg., 2016, 79, 245-
250). [Product Details...] |
Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica