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Georges Brohée Prize
Towards a tailored therapy in pancreatic cancerPrice: €10,00 |
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Pancreatic ductal adenocarcinoma (PDAC) remains a major
unsolved
health problem. As conventional treatments have shown
only a modest impact on disease course, development of new therapeutic
strategies based on the molecular biology of PDAC must be
a high priority. The identification of relevant predictive and prognostic
biomarkers which can be used to select patient subgroups
that may benefit from conventional treatments and new targeted
agents will be of considerable interest. We have demonstrated the
ability of the metabolizing gemcitabine protein (the human Equilibrative
nucleoside transporter 1 and the deoxycytidine kinase) in
predicting the benefit of adjuvant gemcitabine-based therapy in
resected PDAC patients. Beside these predictive biomarkers, we
have evaluated different molecular factors that may impact on the
likely course of this cancer. The chemokine receptor CXCR4 that
has been shown to be implicated in PDAC tumorigenicity and
aggressiveness
could serve as a prognostic marker for survival
after
a curative-intent surgery and was associated with the pattern
of tumour recurrence (distant versus local relapse). Our findings
were validated in an independent cohort of patients. Overall our
results suggested that (i) the benefit of an adjuvant gemcitabinebased
therapy can be predicted based on the tumour expression of
hENT1 and dCK, (ii) CXCR4 is an independent negative prognostic
factor and an independent predictor of distant relapse suggesting
that anti-CXCR4 targeting therapies can be a promising treatment
in combination with cytotoxic chemotherapy in the adjuvant
setting.
These data open new perspectives for designing trials based
on a molecular driven strategy. (Acta gastroenterol.
belg., 2013, 76, 49-56). [Product Details...] |
Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica