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Acta Gastroenterologica Belgica is supported by grants
from its major sponsors
Acta Gastro-Enterologica Belgica is published in
partnership with the following national societies
Reviews
Liver progenitor cells and therapeutic potential of stem cells in human chronic liver diseasesPrice: €10,00 |
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| Liver progenitor cells, thought to reside in the terminal bile
ductules (canals of Hering) at the interface between portal tracts
and liver lobule, proliferate during severe hepatic injury. They
may contribute to hepatocyte regeneration, or even take over this
role if the liver injury is severe and associated with an impairment
of hepatocyte proliferation. They represent promising targets in an
attempt to stimulate liver regeneration in chronic diseases. Recent
studies on liver progenitor cell recruitment in response to injury in
chronic viral hepatitis B, hepatitis C, alcoholic and non-alcoholic
liver diseases are presented in this review, as well as clinical trials
in which stem cells are administered as a therapeutic intervention
to promote liver regeneration. Liver progenitor cell expansion is
part of the disease process itself and may contribute to disease
severity,
mainly related to fibrosis. As the majority of these progenitor
cells tend to acquire a biliary phenotype, their role in liver
repair and improvement in liver function remains to be addressed.
Present data on stem cell therapy are heterogeneous in terms of
methods and endpoints ; thus, results need to be carefully examined
prior to drawing a conclusion on possible benefits. (Acta
gastroenterol.
belg., 2013, 76, 3-9). [Product Details...] |
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Probiotics and IBDPrice: €10,00 |
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| The pathophysiology of inflammatory bowel disease is still
incompletely
understood. While the development of the immune
system and the establishment of the microflora take place during
infancy young patients often have a more severe and extensive disease.
The differences in composition and concentration of intestinal
microbiota and aberrant immune responses towards the luminal
bacteria prompted the concept of an ‘ecological’ approach to
control
the disease course. Probiotics, living, non pathogenic micro
organisms with a beneficial effect on the host, and prebiotics, oligosaccharides
promoting the growth of the beneficial microflora,
have been studied to this effect. Results have so far been disappointing
for Crohn’s disease but encouraging for ulcerative colitis.
An overview of studies using probiotics in adults or children and a
perspective on specific pediatric issues is provided in this review.
(Acta gastroenterol.
belg., 2013, 76, 15-19). [Product Details...] |
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The roles of mesenchymal stem cells in gastric lesion and regeneration : applications in gastric diseasesPrice: €10,00 |
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| In recent years, many studies have focused on the roles of
mesenchymal
stem cells (MSCs) due to their contribution to tissue
regeneration and tumorigenesis. However, the full profile of the
roles of MSCs in gastric diseases has not been established. In this
review, we aim to provide an overview on the roles of MSCs on cell
lesion and regeneration in gastric diseases, including gastric ulcer,
premalignant conditions and cancer. We will also discuss the
mechanisms
underlying the behaviors of MSCs in these diseases.
(Acta gastroenterol.
belg., 2013, 76, 10-14). [Product Details...] |
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Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica