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Reviews
Familial primary biliary cirrhosis : Like mother, like daughter ?Price: €10,00 |
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The reasons underlying why autoimmune diseases overwhelmingly
affect women more than men are not clear. Nor are the reasons
why autoimmune disease is more prevalent in families. This review
uses primary biliary cirrhosis (PBC) as a model autoimmune
disease to discuss the familial risk, focusing mainly on motherdaughter
pairs. PBC is a chronic cholestatic liver disease characterised
by an immune-mediated inflammatory destruction of the
small intrahepatic bile ducts, with fibrosis progressing to cirrhosis
and subsequent liver failure. Epidemiological studies have demonstrated
that first degree relatives of PBC patients are at higher risk
of developing PBC, as well as other autoimmune diseases. This is
especially true for the mothers, daughters and sisters of PBC
patients. Multiple case reports have highlighted the complexity of
mother-daughter pairs in PBC, and the need for follow-up of these
individuals when one member of the pair is diagnosed with PBC. It
may be the case that diagnosis in one individual may lead to early
diagnosis in the other, even if they are asymptomatic. Early
management of PBC may improve the prognosis in these patients.
This review will examine the literature surrounding PBC in
mothers and daughters. (Acta gastro enterol. belg., 2012, 75, 203-209). [Product Details...] |
Molecular changes in pancreatic cancer : implications for molecular targeting therapyPrice: €10,00 |
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Pancreatic ductal adenocarcinoma has a high mortality rate,
which is generally related to the initial diagnosis coming at late
stage disease combined with a lack of effective treatment options.
Gemcitabine has been the most commonly used drug over the past
decade and is still the cornerstone of therapy in adjuvant and
metastatic settings. Intrinsic or acquired resistance of tumours to
gemcitabine is, however, a major clinical problem. New therapeutic
strategies are urgently needed whereas we also need to identify
new prognostic and predictive biomarkers. This article focuses on
gemcitabine resistance, on the role of chemokines and chemokine
receptors in pancreatic carcinoma initiation and progression, and
on stellate cells as partners in crime with neoplastic epithelial cells.
(Acta gastro enterol. belg., 2012, 75, 210-214). [Product Details...] |
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Acta gastroenterologica is abstracted/indexed in Current Contents, Excerpta Medica, Index medicus, ISI.
Published by © Universa Press, Wetteren, Belgium. All rights reserved.
Published by © Universa Press, Wetteren, Belgium. All rights reserved.