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Short review
Irritable bowel syndrome : the role of the intestinal microbiota, pathogenesis and therapeutic targetsPrice: €10,00 |
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Irritable bowel syndrome (IBS) is a functional gastrointestinal
disorder that predominantly affects women and accounts for up to
40% of the gastroenterology unit outpatient visits. The patho -
physiology is complex and multifactorial. In the present review we
will focus on the role of intestinal dysbiosis in its pathogenesis and
treatment.
Post-infectious IBS (PI-IBS) can put light on the mechanisms
underlying IBS. Modified commensal gut flora may lead to mucosal
inflammation. Several changes such as an increase in mucosal
cellularity (enterochromaffin cells, lamina propria T lymphocytes
and mast cells), modified pro-inflammatory/anti-inflammatory
cytokine balance and disordered neurotransmission have been
observed.
The normal microbiota is an essential factor in health. A modification
of the flora, such as small intestinal bacterial overgrowth
(SIBO) is thought to play a pathogenic role in IBS. Changes in the
composition of the luminal and mucosal colonic flora have been
linked to IBS. It is not clear however, whether these changes are a
cause or a consequence of the syndrome. The comprehension of the
interaction between the dysbiotic microbiota and the host will
probably lead to the development of focused therapies.
Based on these assumptions, treatments modulating the microbiota
have been investigated. On the one hand several probiotics
have shown a reduction in IBS symptoms by an immunomodulatory
and analgesic effects. On the other hand antibiotic treatment has
proven efficacy in treating IBS with or without associated SIBO.
Due to its complex pathophysiology, treating IBS nowadays
implies multiple approaches, one of which may be modulation of
the intestinal flora. (Acta gastro enterol. belg., 2011, 74, 375-380). [Product Details...] |
Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica