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Acta Gastroenterologica Belgica is supported by grants
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Acta Gastro-Enterologica Belgica is published in
partnership with the following national societies
Original article
Clinical characteristics of Iranian pediatric patients with inflammatory bowel diseasePrice: €10,00 |
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| Abstract
Background : Inflammatory bowel disease (IBD) is a group of
disorders, including Crohn’s disease (CD), ulcerative colitis (UC)
and indeterminate colitis (IC). Small intestine and colon are primarily
affected in this group of disorders.
Purpose : This single center study was performed to define
demographic features and clinical characteristics of Iranian
pediatric patients with IBD.
Method : Fifty nine patients with IBD, who have been referred to
Children’s Medical Center Hospital during a 10-year period, were
investigated in this study. The data was gathered by interviewing
the patients and their families, as well as reviewing their medical
records.
Results : Among 59 patients with IBD, 23 cases had UC and
19 cases had CD, while the remaining 17 cases had IC. Patients
with UC were significantly younger at the time of diagnosis in comparison
with patients with CD. The most common symptoms were
abdominal pain, diarrhea, fever and growth failure. Hepatobiliary
abnormalities and arthritis were common extra intestinal manifestations.
The median Pediatric Crohn’s Disease Activity Index was
42.5 (range 20-60), whereas the median Pediatric Ulcerative Colitis
Activity Index was 40 (range 20-70). Seven of 23 UC (30.4%) had
proctatis, while 16 (69.6%) had extensive colitis. In CD, 11 of 19
(57.9%) had involvement of terminal ileum and colon, while
inflammation was limited to the colon in 8 cases (42.1%). The
colonoscopic findings in the IC group were heterogeneous.
Conclusion : This study provides epidemiological data on pediatric
patients with IBD, which could be useful for health care
workers in prompt diagnosis and appropriate treatment of early
onset IBD. (Acta gastro enterol. belg., 2009, 72, 230-234). [Product Details...] |
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Effect of addition of vitamin C to clarithromycin-amoxicillin-omeprazol triple regimen on Helicobacter pylori eradicationPrice: €10,00 |
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| Abstract
Background : The use of vitamin C as a supplement with the
common regimen for eradication of Helicobacter pylori infection is
the subject of ongoing controversy. We conducted a prospective
controlled study with the aim of testing whether the vitamin C
supplement to the therapy includes lower dosage of clarithromycin
could have an acceptable influence on Helicobacter pylori eradication
in comparison with routine anti-Helicobacter pylori regimen.
Materials and methods : Two hundred and fourteen consecutive
patients with the verification of Helicobacter pylori infection via
positive Rapid Urease Test (RUT) and histology results were
included and divided into two therapy groups : 1) a group without
vitamin C (n = 100) that were administered 20 mg omeprazol, 1 g
amoxicillin, and 500 mg clarithromycin twice daily for 2 weeks and
2) a triple-plus-vitamin C group (n = 114) that was administered
20 mg omeprazol, 1 g amoxicillin, 250 mg clarithromycin plus
250 mg vitamin C twice daily for 2 weeks. Four weeks after the
completion of therapy, each patient was scheduled for urea breath
test to assess the success of Helicobacter pylori eradication.
Results : Similar eradication of Helicobacter pylori was found
between the triple-only group with 500 mg of clarithromycin and
the triple with 250 mg of clarithromycin-plus vitamin C group
(89% versus 86.8%, P = 0.623).
Conclusions : Adding vitamin C might reduce the needed dosage
of clarithromycin for eradication of Helicobacter pylori. (Acta
gastro enterol. belg., 2009, 72, 222-224). [Product Details...] |
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Quantitative endoscopic and histologic activity assessment of ulcerative colitisPrice: €10,00 |
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| Abstract
Background : Correct assessment of the severity and activity of
ulcerative colitis (UC) is necessary for determining effective treatment
and predicting prognosis. The correlation between histologic
activity and endoscopic activity, however, has not yet been determined
by using a quantitative scoring system.
Study aims : To compare the endoscopic activity index (EAI),
detected during colonoscopy, with the histologic activity index
(HAI) detected in biopsy samples taken from the same colon
segments of UC patients in order to determine the degree of
agreement between both assessments.
Patients and methods : Ninety-six UC patients participated in
this prospective study. EAIs and HAIs were obtained by summing
the scores given for each mucosal/histological change to produce a
total score between 1 and 12. The correlation between EAI and
HAI was calculated.
Results : There was a positive correlation between HAI and EAI
(r = 0.78 ; p [Product Details...] |
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Tumor necrosis factor–alpha gene promoter polymorphisms in Chinese patients with nonalcoholic fatty liver diseasesPrice: €10,00 |
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| Abstract
Background : Nonalcoholic Fatty Liver Disease (NAFLD)
encompasses a histopathological spectrum of clinical conditions
such as simple fatty liver (steatosis), nonalcoholic steatohepatitis
(NASH), and a variant that has degrees of fibrosis. Tumor Necrosis
Factor–alpha (TNF-a) is considered essential for NAFLD.
Therefore, we investigated the correlation between TNF-a gene
promoter polymorphism and NAFLD in this human study.
Patients and methods : The TNF-a gene polymorphisms at position
-238 and -308 were analyzed in 189 Chinese patients with
NAFLD and 138 healthy controls by using polymerase chain reaction
and restriction fragment length polymorphism assay. The
serum levels of TNF-a in both patient and control groups were
measured by ELISA. The associations of TNF-a polymorphism
and serum TNF-a, and/or insulin resistance, and/or clinical
features were analyzed.
Results : The carrier frequencies of TNF-a gene polymorphism
with G/A mutation at -238 were significantly higher in the patients
with NAFLD than those in the control subjects (p 0.05). In
addition, the serum level of TNF-a was markedly higher in the
patients with NAFLD than in the control subjects (p nsulin resistance,
as well as increased body mass index in the NAFLD patients.
Conclusions : The results indicate that the TNF-a gene polymorphism
at position -238 is associated with susceptibility of nonalcoholic
Fatty Liver Disease in a Chinese population. (Acta gastro -
enterol. belg., 2009, 72, 215-221). [Product Details...] |
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Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica