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Symposium
Crohn’s disease phenotype, prognosis, and long-term complications : what to expect ?Price: €10,00 |
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According to Montreal classification, different phenotypes of
Crohn’s disease are defined taking into account age at diagnosis,
localization of digestive lesions at first surgery, and cumulative
anatomical behaviour. This classification is supported by the
increased severity of the disease when diagnosed in childhood, the
relative stability of disease localization over time, and the clinical
importance of intestinal complications as stricture and abscess or
fistula formation. However, type and delay of complications are
dependent on disease localization (they develop early in small
bowel disease and late in colitis), every patient will develop complications
one day, and perianal disease may be an important problem
observed in up to half the patients. The percentage of patients
with active disease every year remains stable, about 40%, after the
3 first years, and only a few patients have long periods of remission.
Intestinal resections are required in the majority of patients during
life, and many are operated on several times. Prognosis is hampered
by iterative surgery, cancer and side-effects of treatment.
Standardized mortality ratio is 1.50. Although occurrence of
complications , need for surgery and mortality did not change
significantly through the years 1950-2000, there are some signals
suggesting that new therapetic strategies (immunosuppressants
earlier in high risk patients) and biologics will modify natural
history and improve the long term prognosis. (Acta gastro enterol.
belg., 2008, 71, 303-307). [Product Details...] |
Molecular imaging in a (pre-) clinical contextPrice: €10,00 |
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Molecular imaging can be defined as imaging of biological
processes in a living organism at the molecular and/or cellular
level. To achieve this goal, genetic information and new chemistries
have to be combined into new imaging probes detectable by sophisticated
imaging techniques. In contradistinction to conventional
imaging, which mostly detects architectural, or morphological distortions
(a late event), molecular imaging should be able to detect
molecular changes that are at the basis of diseases. The detection of
subtle pathologic changes in early, asymptomatic disease should
have a tremendous impact on healthcare as a whole. (Acta gastro -
enterol. belg., 2008, 71, 308-317). [Product Details...] |
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Acta gastroenterologica is abstracted/indexed in Current Contents, Excerpta Medica, Index medicus, ISI.
Published by © Universa Press, Wetteren, Belgium. All rights reserved.
Published by © Universa Press, Wetteren, Belgium. All rights reserved.