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Is HBV genotyping of clinical relevance ?Price: €10,00 |
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The hepatitis B virus, as is the case of the hepatitis C virus, can
be categorized in several genotypes. The genotyping of HBV is
based on the nucleotide sequence divergence encoding the amino
acids constituting the HBV surface proteins. Since the genotype of
the hepatitis C virus is shown to be related to epidemiology and
response to interferon therapy, one wonders whether this also
holds for the hepatitis B virus. HBV genotypes clearly are found to
be different in various geographical areas of infection. In Europe,
genotypes A and D are predominant, whereas in Asian patients
genotypes B and C are more frequent, and in the Middle-East the
genotype D. Data concerning the clinical relevance are less clear
but it seems that in Europe, the genotype A has a higher HBeAg
clearance rate and a better outcome. In Asia, genotype B (and especially
the genotype Bj) is associated with a higher HBeAg clearance
and with less development of cirrhosis and HCC. The impact on
spontaneous or therapy induced viral resolution is not yet clearly
identified. Further evaluation in different countries is needed to
delineate the impact of the genotype relative to other factors such
as age at infection, level of serum transaminases and viral load, on
the course of infection, complication, outcome of treatment and
prognosis. [Product Details...] |
Acta Gastro-Enterologica Belgica is indexed in NCBI/PubMed.
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica
Printed by Universa Press, Wetteren, Belgium. ©vzw/asbl Acta Gastro-Enterologica Belgica