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Original Article

An ultrastructural investigation in stomach epithelial cells of mice during pregnancy and early lactation

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In this study, stomach epithelial cells from adult nonpregnant, pregnant lactating mice were examined by histochemical, immunohistochemical and ultrastructural methods. Tissue samples taken from different groups were stained with haematoxylin-eosin and PAS-alcian blue and semithin sections were stained with toluidin blue for light microscopic examination. For ultrastructural examination ultrathin sections were stained with uranyl acetate and lead citrate. Additionally, by applying immunoperoxidase method, the distribution of EGF receptors of all groups was studied. We concluded that in the pregnant mice, stomach surface had lower mucus than the nonpregnant group. The acid content was balanced in active and inactive parietal cells. Examination results of lactating mice were similar to the results obtained from nonpregnant and pregnant mice. [Product Details...]

Features of chronic inflammation at the gastric cardia and the relationship with Helicobacter pylori infection and oesophagitis

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Background : The etiopathogenesis of chronic inflammation at the gastric cardia is still debated. It is suggested that carditis may be a finding of gastro-oesophageal reflux disease (GORD) or it may occur as a result of the gastritis caused by Helicobacter pylori (H. pylori) infection. Aim : To examine morphological features of carditis, as well as the associations of carditis with Helicobacter pylori gastritis and oesophagitis as a marker of gastro-oesophageal reflux disease. Patients and methods : Endoscopic biopsy specimens obtained systematically from oesophagus, cardia, corpus and antrum of 135 dyspeptic patients were retrospectively evaluated. In biopsies, we have searched for any correlations between clinical, endoscopic, and histological features. Results : Carditis was detected in 123 (91.1%) of the cases. The mean age of the carditis group was 47.9 years and the male-tofemale ratio was 1.08:1. The relation of carditis with age and sex was not significant (p = 0.19 and p = 0.24, respectively). All cases of the carditis group had concomitant chronic gastritis. In these cases, chronic inflammation, degree of neutrophil-mediated activity and H. pylori colonisation were significantly correlated in cardia, corpus and antrum (p < 0.001). Intestinal metaplasia was observed in 14 cases (11.3%) and, was associated with H. pylori colonisation (p < 0.001). Microscopic oesophagitis detected in 37.7% cases also showed correlation with reflux symptoms and endoscopic oesophagitis but not carditis. When all cases with carditis were evaluated for H. pylori infection and oesophagitis, which are presumed risk factors for carditis, H. pylori infection appeared to be an independent risk factor for carditis (p = 0.012), while oesophagitis did not. Conclusions : This study suggests that carditis is commonly found in patients presenting with dyspepsia and the histological features of carditis were similar to those seen in H. pylori gastritis in antrum and corpus. In addition, our data have also shown that carditis was significantly associated with H. pylori infection but not with symptoms or signs of GORD. [Product Details...]

Prevalence of microscopic colitis in patients with symptoms suggesting irritable bowel syndromes

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Goals/Background : Irritable bowel syndrome is a common disorder affecting 20% of the general population. It shows certain characteristics with organic bowel diseases. Definition of lymphocytic and collagenous colitis has created a new approach towards chronic idiopathic diarrheas. We searched for the frequency of lymphocytic and collagenous colitis in patients with irritable bowel syndrome. Study : The study group consisted of 30 irritable bowel patients and 20 controls. Multiple biopsies from cecum ; ascendant, transverse and descendent colon ; sigmoid and rectum were taken sequentially in all patients. Results : We diagnosed 7 out of 30 irritable bowel patients as having lymphocytic colitis (23.3%) but none as having collagenous colitis. In the control group 1 out of 20 patients had lymphocytic colitis (5%) and none had collagenous colitis. Irritable bowel patients had higher rate of lymphocytic colitis association (p < 0.05). Conclusions : Functional disorders of the bowel should be searched for possible lymphocytic colitis, especially in cases refractory to classical therapies. [Product Details...]

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